赵应声

来自 : chemistry.suda.edu.cn/51/00/c2 发布时间：2021-03-24

姓名：赵应声
职称：研究员、博士生导师

部门：材化学院
联系方式：

Tel：86-18662533899

Email：yszhao@suda.edu.cn

课题组网站

学历及学历经历：

2003年7月西南大学获得学士学位；2008年7月武汉大学获理学博士学位（导师雷爱文教授）；2008年10月–2010年9月日本名古屋大学从事博士后研究（Prof. Ryoji Noyori/Saito Sumumu 课题组）；2010年10月–2012年9月美国宾州州立大学从事博士后研究（Prof. Chen gong 课题组）, 2012年底加入苏州大学材料与化学化工学部开始独立科研工作,历任副教授（2012）、教授（2018），博士生导师（2018年）；目前主持国家自然科学基金、江苏省基础研究计划（自然科学基金）。在国际著名化学期刊如Nat. Commun., J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Chem. Commun.,Org. Lett.等发表学术论文50多篇，发表SCI检索论文被他引1600余次。

曾获湖北省优秀博士论文（2008）；湖北省科学技术奖一等奖（排名第三），苏州大学东吴学者（2016），江苏省杰出青年基金获得者（2018）；Thieme Chemistry Journal Award(2018)。

研究方向及领域：

区域选择性碳氢键活化反应，碳氢键氟化学策略地研究；小分子（CO，CO2，NO，O2等）活化及天然产物和生物活性分子半合成地研究。

代表性论文：

1. Yuan, C.; Lan, Y.; Zhao. Y.*;Ruthenium(II)-enabled para-Selective C-H Difluoromethyla-tionof Anilides, Indolines and Tetrahydroquinolines, Nat. commun. 2018,9(1), 1189.

2. Zhu, Y.; Chen, X.; Yuan, C.; Li, G.; Zhao, Y.*, Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids. Nat. commun. 2017,8, 14904.3

3. Yuan, C.; Zhu. L; Lan, Y.*; Zhao. Y.*;Ruthenium(II)-catalzyed C-H Difluoromethylation of Ketoxime: Tunning the Regioselectivity from metato paraPosition;Angew. Chem. Int. Ed. 2018,57(5), 1277-1281.

4. Wang, C.; Chen, C.; Zhang, J.; Han, J.; Wang, Q.; Guo, K.; Liu, P.; Guan, M.; Yao, Y.*; Zhao, Y.*,Easily Accessible Auxiliary for Palladium-Catalyzed Intramolecular Amination of C(sp2)H and C(sp3)-H Bonds at δ- and ε-Positions. Angew. Chem. Int. Ed. 2014,53(37), 9884-9888.

5. Li, G.; Li, D.; Zhang, J.; Shi, D.-Q.*; Zhao, Y.*, Ligand-Enabled Regioselectivity in the Oxidative Cross-coupling of Arenes with Toluenes and Cycloalkanes Using Ruthenium Catalysts: Tuning the Site-Selectivity from the ortho to meta Positions. ACS Catal. 2017,7(6), 4138-4143.

6. Wang, C.; Zhang, L.; Chen, C.; Han, J.; Yao, Y.*; Zhao, Y.*, Oxalyl amide assisted palladium-catalyzed synthesis of pyrrolidones via carbonylation of [gamma]-C(sp3)-H bonds of aliphatic amine substrates.Chem. Sci.2015,6(8), 4610-4614.

7. Wang, Q.; Han, J.; Wang, C.; Zhang, J.; Huang, Z.; Shi, D.*;Zhao, Y.*, Highly site-selective sequential alkenylation of oxalyl amide protected phenylpropylamine derivatives via a seven-membered palladacycle. Chem. Sci.2014,5(12), 4962-4967.

8. Yuan, C.; Tu, G.; Zhao, Y., Rhodium(III)-Catalyzed Selective Monoarylation of beta or gamma C(sp3)-H Bonds Assisted by a Trimethylpyrazole Group.Org. Lett.2017,19(2), 356-359.

9. Chen, C.; Guan, M.; Zhang, J.; Wen, Z.;Zhao, Y., Palladium-Catalyzed Oxalyl Amide Directed Silylation and Germanylation of Amine Derivatives. Org. Lett.2015,17(15), 3646-3649.

10. Guo, K.; Chen, X.; Guan, M.; Zhao, Y.,Direct ortho-C–H Functionalization of Aromatic Alcohols Masked by Acetone Oxime Ether via exo-Palladacycle. Org. Lett.2015,17(7), 1802-1805.

11. Han, J.; Liu, P.; Wang, C.; Wang, Q.; Zhang, J.; Zhao, Y.; Shi, D.; Huang, Z.; Zhao, Y., Oxalyl Amide Assisted Palladium-Catalyzed Arylation of C(sp2)–H Bond at the δ Position. Org. Lett.2014,16(21), 5682-5685.

12. Hu, J.; Li, G.; Yuan, C.; Huang, Z.-B.; Shi, D.-Q.; Zhao, Y., Rhodium(III)-Catalyzed Oxidative C–H/C–H Cross-Coupling of Heteroarenes and Masked Benzylamines. Org. Lett.2016,18(23), 5998-6001.

13. Chen, X.; Han, J.; Zhu, Y.; Yuan, C.; Zhang, J.; Zhao, Y.,Transformation of masked benzyl alcohols to o-aminobenzaldehydes through C-H activation: a facile approach to quinazolines. Chem. Commun. 2016,52(67), 10241-10244.

14. Guan, M.; Chen, C.; Zhang, J.; Zeng, R.; Zhao, Y.,Palladium-catalyzed oxalyl amide assisted direct ortho-alkynylation of arylalkylamine derivatives at positions. Chem. Commun. 2015,51(60), 12103-12106.

15. Guan, M.; Pang, Y.; Zhang, J.; Zhao, Y., Pd-Catalyzed sequential [small beta]-C(sp3)-H arylation and intramolecular amination of [small delta]-C(sp2)-H bonds for synthesis of quinolinones via an N,O-bidentate directing group. Chem. Commun. 2016,52(43), 7043-7046.

16. Han, J.; Zhang, L.; Zhu, Y.; Zheng, Y.; Chen, X.; Huang, Z.-B.; Shi, D.-Q.; Zhao, Y., Highly regioselective meta arylation of oxalyl amide-protected [small beta]-arylethylamine via the Catellani reaction. Chem. Commun.2016,52(42), 6903-6906.

17. Chen, C.; Wang, C.; Zhang, J.; Zhao, Y., Palladium-Catalyzed ortho-Selective C–H Fluorination of Oxalyl Amide-Protected Benzylamines. J. Org. Chem.2015,80(2), 942-949.

18. Guo, K.; Chen, X.; Zhang, J.; Zhao, Y., Palladium(II)-Catalyzed Acetoxime Directed ortho-Arylation of Aromatic Alcohols. Chem. Eur. J.2015,21(48), 17474-17478.

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博士及博士后期间代表性工作:

1. Zhao, Y.; Wang, H.; Hou, X.; Hu, Y.; Lei, A.; Zhang, H.; Zhu, L., J. Am. Chem. Soc. 2006,128, 15048-15049.

2. Zhao, Y.; Jin, L.; Li, P.; Lei, A., J. Am. Chem. Soc. 2008,130(29), 9429-9433.

3. Zhao, Y.; Foo, S. W.; Saito, S., Angew. Chem. Int. Ed. 2011,50(13), 3006-3009.